Ukuyanga, ukushaya indlwabu kanye nokunqanda akuthwali lutho lwe-HIV. Ukumunca isitho sangasese, uku khotha indunu, ukugibela ngocansi kwekhondomu, ukulala phansi kuthwala ingozi ephansi kakhulu ye-HIV. Ukugibela ngaphandle kwekhondomu kuthatha ingozi ephakathi ye-HIV, futhi ukulala phansi ngaphandle kwekhondomu kuthatha ingozi enkulu.
Lokhu kusebenza kuphela kwi-HIV, hhayi ngezinye izifo ze-STD ezifana ne-drophu, i-gonorrhea, i-klamidiya, noma isifo sesibindi.